At this years Barts Research and Advanced Interventional Neuroradiolgy (BRAIN) conference Hereditary Brain Aneurysm Support showcased a poster illustrating a Targeted Literature Review on the epidemiology, genetic causes and guidelines for familial brain aneurysms.
About BRAIN Conference 2023
BRAIN Conference is an annual event led by course directors Paul Bhogal, Levansri Makalanda and Oliver Spooner of Barts Health NHS Trust.
At BRAIN Conference 2023 Rebecca Middleton, founder of HBA Support joined neuroradiologists, endovascular neurosurgeons and allied health professionals from all over the world, convening on several topics, including stroke, aneurysms, new technology and more.
BRAIN Conference is a compliant course by MedTech Europe, the European trade association for the medical technology industry including diagnostics, medical devices and digital health, and so HBA Support was honoured to be attending the event.
Below are the references from the poster on display during the conference. The full Targeted Literature Review is available as a free download.
Poster reference table
| Targeted Literature Review reference | BRAIN Poster reference | Detail |
| 14 | 1 | Keuss SE, Parker TD, Lane CA, et al. Incidental findings on brain imaging and blood tests: results from the first phase of Insight 46, a prospective observational substudy of the 1946 British birth cohort. BMJ Open 2019;9:e029502. |
| 16 | 2 | Jalava I, Pyysalo L, Alanen M, et al. Regional differences in the incidence of aneurysmal subarachnoid haemorrhage in Finland. Acta Neurochir (Wien) 2017;159:1657-1662. |
| 18 | 3 | Broderick JP, Brown RD, Jr., Sauerbeck L, et al. Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms. Stroke 2009;40:1952-57. |
| 19 | 4 | Brown BM, Soldevilla F. MR angiography and surgery for unruptured familial intracranial aneurysms in persons with a family history of cerebral aneurysms. AJR Am J Roentgenol 1999;173:133-138. |
| 20 | 5 | Brown RD, Jr., Huston J, Hornung R, et al. Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection. J Neurosurg 2008;108:1132-1138. |
| 21 | 6 | Chan DY, Abrigo JM, Cheung TC, et al. Screening for intracranial aneurysms? Prevalence of unruptured intracranial aneurysms in Hong Kong Chinese. J Neurosurg 2016;124:1245-1249. |
| 22 | 7 | Goksu E, Akyuz M, Tuncer R. The results of radiological screening in asymptomatic at-risk members of intracranial aneurysm families from the Turkish population. Turk Neurosurg 2012;22:55-61. |
| 23 | 8 | Kojima M, Nagasawa S, Lee YE, et al. Asymptomatic familial cerebral aneurysms. Neurosurgery 1998;43:776- 781. |
| 24 | 9 | Leblanc R, Worsley KJ, Melanson D, et al. Angiographic screening and elective surgery of familial cerebral aneurysms: a decision analysis. Neurosurgery 1994;35:9- 18; discussion 18-19. |
| 25 | 10 | Wang MC, Rubinstein D, Kindt GW, et al. Prevalence of intracranial aneurysms in first-degree relatives of patients with aneurysms. Neurosurg Focus 2002;13:e2. |
| 26 | 11 | Bor AS, Rinkel GJ, van Norden J, et al. Long-term, serial screening for intracranial aneurysms in individuals with a family history of aneurysmal subarachnoid haemorrhage: a cohort study. Lancet Neurol 2014;13:385-392. |
| 27 | 12 | Ronkainen A, Miettinen H, Karkola K, et al. Risk of harboring an unruptured intracranial aneurysm. Stroke 1998;29:359-362. |
| 28 | 13 | Galassi W, Yuyangkate W, Paholthep P, et al. Prevalence of unruptured intracranial aneurysms among first- degree relatives of Thai patients who had aneurysmal subarachnoid hemorrhage. Surg Neurol Int 2021;12:566 |
| 29 | 14 | Agarwal N, Gala NB, Choudhry OJ, et al. Prevalence of asymptomatic incidental aneurysms: a review of 2,685 computed tomographic angiograms. World Neurosurg 2014;82:1086-1090. |
| 30 | 15 | Asaithambi G, Adil MM, Chaudhry SA, et al. Incidences of unruptured intracranial aneurysms and subarachnoid hemorrhage: results of a statewide study. J Vasc Interv Neurol 2014;7:14-17. |
| 31 | 16 | Bos D, Poels MM, Adams HH, et al. Prevalence, Clinical Management, and Natural Course of Incidental Findings on Brain MR Images: The Population-based Rotterdam Scan Study. Radiology 2016;281:507-515. |
| 32 | 17 | Harada K, Fukuyama K, Shirouzu T, et al. Prevalence of unruptured intracranial aneurysms in healthy asymptomatic Japanese adults: differences in gender and age. Acta Neurochir (Wien) 2013;155:2037-2043. |
| 33 | 18 | Horikoshi T, Akiyama I, Yamagata Z, et al. Retrospective analysis of the prevalence of asymptomatic cerebral aneurysm in 4518 patients undergoing magnetic resonance angiography--when does cerebral aneurysm develop? Neurol Med Chir (Tokyo) 2002;42:105-112; discussion 113. |
| 34 | 19 | Igase K, Matsubara I, Igase M, et al. Initial experience in evaluating the prevalence of unruptured intracranial aneurysms detected on 3-tesla MRI. Cerebrovasc Dis 2012;33:348-353. |
| 35 | 20 | Inagawa T, Hirano A. Autopsy study of unruptured incidental intracranial aneurysms. Surg Neurol 1990;34:361-365. |
| 36 | 21 | Jeon TY, Jeon P, Kim KH. Prevalence of unruptured intracranial aneurysm on MR angiography. Korean J Radiol 2011;12:547-553. |
| 37 | 22 | Kim JH, Lee KY, Ha SW, et al. Prevalence of Unruptured Intracranial Aneurysms: A Single Center Experience Using 3T Brain MR Angiography. Neurointervention 2021;16:117-121. |
| 38 | 23 | Kobayashi H, Tsuji T, Ishii H, et al. Diagnosis of unruptured asymptomatic cerebral aneurysms by magnetic resonance angiography. J Clin Neurosci 1997;4:197-200. |
| 39 | 24 | Li J, Shen B, Ma C, et al. 3D contrast enhancement- MR angiography for imaging of unruptured cerebral aneurysms: a hospital-based prevalence study. PLoS One 2014;9:e114157. |
| 40 | 25 | Li MH, Chen SW, Li YD, et al. Prevalence of unruptured cerebral aneurysms in Chinese adults aged 35 to 75 years: a cross-sectional study. Ann Intern Med 2013;159:514-521. |
| 41 | 26 | Müller TB, Sandvei MS, Kvistad KA, et al. Unruptured intracranial aneurysms in the Norwegian Nord-Trøndelag Health Study (HUNT): risk of rupture calculated from data in a population-based cohort study. Neurosurgery 2013;73:256-261. |
| 42 | 27 | Nakagawa T, Hashi K. The incidence and treatment of asymptomatic, unruptured cerebral aneurysms. J Neurosurg 1994;80:217-223. |
| 43 | 28 | Thien A, See AA, Ang SY, et al. Prevalence of Asymptomatic Unruptured Intracranial Aneurysms in a Southeast Asian Population. World Neurosurg 2017;97:326-332. |
| 44 | 29 | Vernooij MW, Ikram MA, Tanghe HL, et al. Incidental findings on brain MRI in the general population. N Engl J Med 2007;357:1821-1828. |
| 45 | 30 | Winn HR, Jane JA, Sr., Taylor J, et al. Prevalence of asymptomatic incidental aneurysms: review of 4568 arteriograms. J Neurosurg 2002;96:43-49. |
| 46 | 31 | Yue NC, Longstreth WT, Jr., Elster AD, et al. Clinically serious abnormalities found incidentally at MR imaging of the brain: data from the Cardiovascular Health Study. Radiology 1997;202:41-46. |
| 47 | 32 | Ronkainen A, Hernesniemi J, Puranen M, et al. Familial intracranial aneurysms. Lancet 1997;349:380-384. |
| 48 | 33 | Iwamoto H, Kiyohara Y, Fujishima M, et al. Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy series during a 30- year observation period. The Hisayama study. Stroke 1999;30:1390-1395. |
| 49 | 34 | Kapoor K, Kak VK. Incidence of intracranial aneurysms in north-west Indian population. Neurol India 2003;51:22-6. |
| 50 | 35 | Mostafazadeh B, Farzaneh Sheikh E, Afsharian Shishvan T, et al. The incidence of berry aneurysm in the Iranian population: an autopsy study. Turk Neurosurg 2008;18:228-31. |
| 51 | 36 | Thulung S, Aryal B, Baniya A, et al. Prevalence of Ruptured Intracranial Aneurysms in a Tertiary Care Hospital of Nepal. JNMA J Nepal Med Assoc 2019;57:168-171. |
| 52 | 37 | Bechstein M, Gansukh A, Regzengombo B, et al. Risk Factors for Cerebral Aneurysm Rupture in Mongolia. Clin Neuroradiol 2021;32:499-506. |
| 53 | 38 | Fukuhara T. Geographical analysis of aneurysmal subarachnoid hemorrhage in Japan utilizing publically- accessible DPC database. PLoS One 2015;10:e0122467. |
| 54 | 39 | Hamada J, Morioka M, Yano S, et al. Incidence and early prognosis of aneurysmal subarachnoid hemorrhage in Kumamoto Prefecture, Japan. Neurosurgery 2004;54:31-8. |
| 55 | 40 | Huang H, Lai LT. Incidence and Case-Fatality of Aneurysmal Subarachnoid Hemorrhage in Australia, 2008- 2018. World Neurosurg 2020;144:e438-e446. |
| 56 | 41 | Inagawa T, Ishikawa S, Aoki H, et al. Aneurysmal subarachnoid hemorrhage in Izumo City and Shimane Prefecture of Japan. Incidence. Stroke 1988;19:170-175. |
| 57 | 42 | Keris V, Buks M, Macane I, et al. Aneurysmal subarachnoid hemorrhage in Baltic population: experience from Latvia (1996-2000). Eur J Neurol 2002;9:601-607. |
| 58 | 43 | Lee HS, Kim YJ, You SH, et al. The incidence of aneurysmal subarachnoid hemorrhage in youngdong district, Korea. J Korean Neurosurg Soc 2007;42:258-264. |
| 59 | 44 | Lee WK, Oh CW, Lee H, et al. Factors influencing the incidence and treatment of intracranial aneurysm and subarachnoid hemorrhage: time trends and socioeconomic disparities under an universal healthcare system. J Neurointerv Surg 2019;11:159-165. |
| 60 | 45 | Marks PV, Hope JK, Cluroe AD, et al. Racial differences between Maori and European New Zealanders in aneurysmal subarachnoid haemorrhage. Br J Neurosurg 1993;7:175-181. |
| 61 | 46 | Mathieu J, Pérusse L, Allard P, et al. Epidemiological study of reptured intracranial aneurysms in the Saguenay-Lac- Saint-Jean region (Quebec, Canada). Can J Neurol Sci 1996;23:184-188. |
| 62 | 47 | Nogueira GJ. Spontaneous subarachnoid haemorrhage and ruptured aneurysms in the Middle East. A myth revisited. Acta Neurochir (Wien) 1992;114:20-25. |
| 63 | 48 | Ohkuma H, Fujita S, Suzuki S. Incidence of aneurysmal subarachnoid hemorrhage in Shimokita, Japan, from 1989 to 1998. Stroke 2002;33:195-199. |
| 64 | 49 | Øie LR, Solheim O, Majewska P, et al. Incidence and case fatality of aneurysmal subarachnoid hemorrhage admitted to hospital between 2008 and 2014 in Norway. Acta Neurochir (Wien) 2020;162:2251-2259. |
| 65 | 50 | Oyoshi T, Nakayama M, Kuratsu J. Relationship between aneurysmal subarachnoid hemorrhage and climatic conditions in the subtropical region, Amami-Oshima, in Japan. Neurol Med Chir (Tokyo) 1999;39:585-90; discussion 590-591. |
| 66 | 51 | Rahmanian A, Jamali M, Bagheri Lankarani K, et al. Aneurysmal subarachnoid haemorrhage (aSAH): Five consecutive years’ experience of Fars province, Iran. PLoS One 2017;12:e0189005. |
| 67 | 52 | Roessler K, Cejna M, Zachenhofer I. Aneurysmatic subarachnoidal haemorrhage: incidence and location of small ruptured cerebral aneurysms - a retrospective population-based study. Wien Klin Wochenschr 2011;123:444-449. |
| 68 | 53 | Sandvei MS, Mathiesen EB, Vatten LJ, et al. Incidence and mortality of aneurysmal subarachnoid hemorrhage in two Norwegian cohorts, 1984-2007. Neurology 2011;77:1833-1839. |
| 69 | 54 | Sandvei MS, Romundstad PR, Müller TB, et al. Risk factors for aneurysmal subarachnoid hemorrhage in a prospective population study: the HUNT study in Norway. Stroke 2009;40:1958-1962. |
| 70 | 55 | Schatlo B, Fung C, Stienen MN, et al. Incidence and Outcome of Aneurysmal Subarachnoid Hemorrhage: The Swiss Study on Subarachnoid Hemorrhage (Swiss SOS). Stroke 2021;52:344-347. |
| 71 | 56 | Tamasauskas A, Tamasauskas J, Bernotas G, et al. Management of patients with ruptured cerebral aneurysms in hospital population of Lithuania. Acta Neurochir (Wien) 2000;142:51-59. |
| 72 | 57 | Ziemba-Davis M, Bohnstedt BN, Payner TD, et al. Incidence, epidemiology, and treatment of aneurysmal subarachnoid hemorrhage in 12 midwest communities. J Stroke Cerebrovasc Dis 2014;23:1073-1082. |
| 73 | 58 | Lee SU, Kim T, Kwon OK, et al. Trends in the Incidence and Treatment of Cerebrovascular Diseases in Korea : Part I. Intracranial Aneurysm, Intracerebral Hemorrhage, and Arteriovenous Malformation. J Korean Neurosurg Soc 2020;63:56-68. |
| 74 | 59 | Majewska P, Gulati S, Øie L, et al. Smoking habits and detection rate of unruptured intracranial aneurysms and incidence rate of subarachnoid haemorrhage in Norway between 2008 and 2015. Acta Neurochir (Wien) 2020;162:3161-3165. |
| 75 | 60 | Gabriel RA, Kim H, Sidney S, et al. Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined population. Stroke 2010;41:21-26. |
| 76 | 61 | Kim T, Lee H, Ahn S, et al. Incidence and risk factors of intracranial aneurysm: A national cohort study in Korea. Int J Stroke 2016;11:917-927. |
| 77 | 62 | Menghini VV, Brown RD, Jr., Sicks JD, et al. Incidence and prevalence of intracranial aneurysms and hemorrhage in Olmsted County, Minnesota, 1965 to 1995. Neurology 1998;51:405-411 |
| 78 | 63 | Raja IA, Javaid MA. Aneurysm surgery in Pakistan. Neurol Med Chir (Tokyo) 1998;38 Suppl:134-137. |
| 79 | 64 | Park S, Lee DH, Ryu CW, et al. Incidental Saccular Aneurysms on Head MR Angiography: 5 Years’ Experience at a Single Large-Volume Center. J Stroke 2014;16:189- 194. |
| 80 | 65 | Isaksen J, Egge A, Waterloo K, et al. Risk factors for aneurysmal subarachnoid haemorrhage: the Tromsø study. J Neurol Neurosurg Psychiatry 2002;73:185-187. |
| 81 | 66 | Inagawa T. Trends in incidence and case fatality rates of aneurysmal subarachnoid hemorrhage in Izumo City, Japan, between 1980-1989 and 1990-1998. Stroke 2001;32:1499-1507. |
| 17 | 67 | Mensing LA, Greving JP, Verhoeff TA, et al. Comparison of Rupture Risk of Intracranial Aneurysms Between Familial and Sporadic Patients. Stroke 2019;50:1380-1383. |
| 5 | 68 | Onda H, Kasuya H, Yoneyama T, et al. Genomewide- linkage and haplotype-association studies map intracranial aneurysm to chromosome 7q11. Am J Hum Genet 2001;69:804-819. |
| 92 | 69 | Akagawa H, Narita A, Yamada H, et al. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. Hum Genet 2007;121:377-387. |
| 94 | 70 | Bourcier R, Le Scouarnec S, Bonnaud S, et al. Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm. Am J Hum Genet 2018;102:133-141. |
| 95 | 71 | Deka R, Koller DL, Lai D, et al. The relationship between smoking and replicated sequence variants on chromosomes 8 and 9 with familial intracranial aneurysm. Stroke 2010;41:1132-1137. |
| 96 | 72 | Ding X, Zhao S, Zhang Q, et al. Exome sequencing reveals a novel variant in NFX1 causing intracranial aneurysm in a Chinese family. J Neurointerv Surg 2020;12:221-226. |
| 97 | 73 | Farlow JL, Lin H, Sauerbeck L, et al. Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm. PLoS One 2015;10:e0121104. |
| 98 | 74 | Farnham JM, Camp NJ, Neuhausen SL, et al. Confirmation of chromosome 7q11 locus for predisposition to intracranial aneurysm. Hum Genet 2004;114:250-255. |
| 99 | 75 | Foroud T, Koller DL, Lai D, et al. Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk. Stroke 2012;43:2846-2852. |
| 100 | 76 | Foroud T, Sauerbeck L, Brown R, et al. Genome screen in familial intracranial aneurysm. BMC Med Genet 2009;10:3. |
| 101 | 77 | Foroud T, Sauerbeck L, Brown R, et al. Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study. Stroke 2008;39:1434-1440. |
| 102 | 78 | Hashikata H, Liu W, Inoue K, et al. Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. Stroke 2010;41:1138-1144. |
| 106 | 79 | Hostettler IC, O’Callaghan B, Bugiardini E, et al. ANGPTL6 genetic variants are an underlying cause of familial intracranial aneurysms. Neurology 2021 ;96:e947-955. |
| 109 | 80 | Li M, Dong X, Chen S, et al. Genetic polymorphisms and transcription profiles associated with intracranial aneurysm: a key role for NOTCH3. Aging (Albany NY) 2019;11:5173-5191. |
| 111 | 81 | Mineharu Y, Inoue K, Inoue S, et al. Model-based linkage analyses confirm chromosome 19q13.3 as a susceptibility locus for intracranial aneurysm. Stroke 2007;38:1174-8. |
| 114 | 82 | Ruigrok YM, Wijmenga C, Rinkel GJ, et al. Genomewide linkage in a large Dutch family with intracranial aneurysms: replication of 2 loci for intracranial aneurysms to chromosome 1p36.11-p36.13 and Xp22.2-p22.32.Stroke 2008;39:1096-1102. |
| 118 | 83 | Sauvigny T, Alawi M, Krause L, et al. Exome sequencing in 38 patients with intracranial aneurysms and subarachnoid hemorrhage. Journal of neurology 2020;267:2533-2545. |
| 119 | 84 | van der Voet M, Olson JM, Kuivaniemi H, et al. Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome |
| 120 | 85 | Wu Y, Li Z, Shi Y, et al. Exome Sequencing Identifies LOXL2 Mutation as a Cause of Familial Intracranial Aneurysm. World Neurosurg 2018;109:e812-e818. |
| 121 | 86 | Yamada S, Utsunomiya M, Inoue K, et al. Genome-wide scan for Japanese familial intracranial aneurysms: linkage to several chromosomal regions. Circulation 2004;110:3727-3733. |
| 122 | 87 | Yamada S, Utsunomiya M, Inoue K, et al. Absence of linkage of familial intracranial aneurysms to 7q11 in highly aggregated Japanese families. Stroke 2003;34:892-900. |
| 124 | 88 | Yang, X., Li, J., Fang, Y., Zhang, et al. Rho guanine nucleotide exchange factor ARHGEF17 is a risk gene for intracranial aneurysms. Circulation: Genomic and Precision Medicine 2018;11:p.e002099. |
| 127 | 89 | Jourdan-Le Saux C, Le Saux O, Donlon T, et al. The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21. 2–p21. 3. Genomics 1998;51:305-307. |
| 128 | 90 | National Center for Biotechnology Information. ARHGEF17 Rho guanine nucleotide exchange factor 17 - NIH Genetic Testing Registry (GTR), 2022.https://www.ncbi.nlm.nih.gov/gtr/genes/9828/.. Accessed 26/07/2022. |
| 129 | 91 | MedlinePlus. NOTCH3 gene. National Library of Medicine, 2016. https://medlineplus.gov/genetics/gene/notch3/ . Accessed 20/03/2022. |
| 130 | 92 | The Human Protein Atlas. ANGPTL6 protein expression summary. https://www.proteinatlas.org/ ENSG00000130812-ANGPTL6. Accessed 26/07/2022. |
| 92 | 93 | Akagawa H, Narita A, Yamada H, et al. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. Hum Genet 2007;121:377-387. |
| 94 | 94 | Bourcier R, Le Scouarnec S, Bonnaud S, et al. Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm. Am J Hum Genet 2018;102:133-141. |
| 95 | 95 | Deka R, Koller DL, Lai D, et al. The relationship between smoking and replicated sequence variants on chromosomes 8 and 9 with familial intracranial aneurysm. Stroke 2010;41:1132-1137. |
| 96 | 96 | Ding X, Zhao S, Zhang Q, et al. Exome sequencing reveals a novel variant in NFX1 causing intracranial aneurysm in a Chinese family. J Neurointerv Surg 2020;12:221-226. |
| 97 | 97 | Farlow JL, Lin H, Sauerbeck L, et al. Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm. PLoS One 2015;10:e0121104. |
| 99 | 98 | Foroud T, Koller DL, Lai D, et al. Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk. Stroke 2012;43:2846-2852. |
| 102 | 99 | Hashikata H, Liu W, Inoue K, et al. Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. Stroke 2010;41:1138-1144. |
| 106 | 100 | Hostettler IC, O’Callaghan B, Bugiardini E, et al. ANGPTL6 genetic variants are an underlying cause of familial intracranial aneurysms. Neurology 2021 ;96:e947-955. |
| 109 | 101 | Li M, Dong X, Chen S, et al. Genetic polymorphisms and transcription profiles associated with intracranial aneurysm: a key role for NOTCH3. Aging (Albany NY) 2019;11:5173-5191. |
| 120 | 102 | Wu Y, Li Z, Shi Y, et al. Exome Sequencing Identifies LOXL2 Mutation as a Cause of Familial Intracranial Aneurysm. World Neurosurg 2018;109:e812-e818. |
| 124 | 103 | Yang, X., Li, J., Fang, Y., Zhang, et al. Rho guanine nucleotide exchange factor ARHGEF17 is a risk gene for intracranial aneurysms. Circulation: Genomic and Precision Medicine 2018;11:p.e002099. |
| 5 | 104 | Onda H, Kasuya H, Yoneyama T, et al. Genomewide-linkage and haplotype-association studies map intracranial aneurysm to chromosome 7q11. Am J Hum Genet 2001;69:804-819. |
| 95 | 105 | Deka R, Koller DL, Lai D, et al. The relationship between smoking and replicated sequence variants on chromosomes 8 and 9 with familial intracranial aneurysm. Stroke 2010;41:1132-1137. |
| 98 | 106 | Farnham JM, Camp NJ, Neuhausen SL, et al. Confirmation of chromosome 7q11 locus for predisposition to intracranial aneurysm. Hum Genet 2004;114:250-255. |
| 99 | 107 | Foroud T, Koller DL, Lai D, et al. Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk. Stroke 2012;43:2846-2852. |
| 101 | 108 | Foroud T, Sauerbeck L, Brown R, et al. Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study. Stroke 2008;39:1434-1440. |
| 115 | 109 | Santiago-Sim T, Depalma SR, Ju KL, et al. Genomewide linkage in a large Caucasian family maps a new locus for intracranial aneurysms to chromosome 13q. Stroke 2009;40:S57-60. |
| 116 | 110 | Santiago-Sim T, Fang X, Hennessy ML, et al. THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Stroke 2016;47:3005-3013. |
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