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UPDATED 2025 - Finding The Hidden Connection Between Menopause And Brain Aneurysms: Our Pledge To Build Greater Awareness And Research

Last year we made a pledge on World Menopause Day 2024, to focus on women – their risk of having an aneurysm and their risk of aneurysm rupture, especially those who have gone through the menopause.

 

Women are already more likely than men to develop brain aneurysms, with studies showing they are 1.5 times more likely to be affected. But after menopause, the risk rises sharply, increasing to 2.2 times more than in men.

 

So why is this? The truth is, we don’t fully know. There are several theories, one of which focuses on estrogen, a hormone that helps maintain the elasticity of blood vessels. As estrogen levels drop after menopause, the ability of blood vessels to remain flexible may be reduced, potentially increasing the risk of aneurysm formation. In addition to this, there’s evidence that inflammation could be a contributing factor, further complicating our understanding of the mechanisms at play.

 



While the influence of genetics is also being explored, especially for women with a family history of brain aneurysms, the lack of concrete answers leaves many questions unanswered.

 

What we do know is that there are huge gaps in the information, no tailored advice, a lack of conclusive research available and that the women in the UK deserve better, especially those who have a strong family history of aneurysms.  For the women affected by this increased risk—particularly those who already have a history of aneurysms in their family—this uncertainty can be both worrying and frustrating.

 

At HBA Support, we believe it’s time to address this head on. That’s why we’re pleased to support genetic research that will look at these critical questions and find much needed answers.


Our Pledge for World Menopause Day - UPDATED 2025


On Menopause Awareness Day 2024, we pledged to take action across four key commitments. Here's how we are getting on:

  1. Engaging with researchers who are working to increase knowledge and understanding of brain aneurysms, specifically in relation to menopause.

    UPDATE: Our work as Patient Partners for the ROAR Study continues and we look forward to the results soon. We also remain in dialogue with researchers who appreciate and understand the need to find out about the increased risk post menopause. We remain hopeful that more research and discovery is on its way.

  1. Understanding and sharing current research with our community, ensuring women have access to the latest findings and advice.

    UPDATE: We've just launched a New Patient Guide and are working to have this available in every Neurocentre in England soon.

  1. Recognising the gaps in knowledge and pushing for answers by advocating for more research, particularly on the link between menopause and aneurysm risk.

    UPDATE: Our Pathway study and patient surveys last year are lighting our way with important policy work to be announced soon, so stay tuned.

  1. Calling for personalised care options for women pre-post-menopause, balancing the need to information and joint decision making with care professionals.

    UPDATE: this remains a priority to explore after the ROAR results are released. With more understanding, we will have more answers.

These promises are not just words. We know there is a long road ahead in terms of research, but by working together with the medical community, researchers, and our supporters, we can start important dialogues and begin to bridge the gap in understanding, ensuring women receive the care and attention they deserve during this stage of life. The knowledge gap may be wide, but with the right research and community support, we can start to close it.


Further Reading


If you’d like to learn more about the connection between menopause and brain aneurysms, here is some academic research you may like to read:


More about Hereditary Brain Aneurysm Support


Contact us by email - support@hbasupport.org

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Hereditary Brain Aneurysm Support (HBA Support) is a charity registered in England and Wales. Registered Charity Number 1210213

Our registered address is HBA Support, The Old Police Station, South Street, Ashby de la Zouch, Leicestershire, LE65 1BR

 

Hereditary Brain Aneurysm Support provides information and support for individuals and families affected by brain aneurysms with a proven or suspected hereditary link. We also aim to raise awareness and help people understand brain aneurysms better. 

 

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare professional for personalised guidance.

For site issues, please email support@hbasupport.org

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